Using Human Skin in Permeation Studies: Ethics, Regulations and Models

October 10, 2023

First, we will look at similarities and differences in ethics and mandatory regulations for the use of human biological samples in research in developed countries around the world. In other words, what you need to know before starting to use human skin for permeation studies. Second, we’ll discuss the different in vitro models for permeation studies, particularly the pros and cons of the models, such as cost, availability, and quality. ​The topics discussed during the webinar are ethics and regulatory considerations you must know and cannot overlook to carry out your research. 

Our speaker for this session is Dr. Laetitia Rapetti, co-founder of Alphenyx, a company aiming to provide alternative solutions to animal testing for research, in 2014. She is the company’s Chief Scientist Officer and an ex​pert specialist in human skin models for permeation studies.

In Vitro Permeation as a Development Tool for Transdermal and Topical Patches

June 20, 2023

During the development of a transdermal patch, the in vitro permeation studies are an essential and useful tool to investigate new formulations regarding the potential of API diffusion through the skin. Because the range of possibilities for the design of a new TTS is broad, the setup design of in vitro permeation must be variable and chosen individual regarding the characteristics of an API and its formulations. In this webinar, we cover how a semiautomated diffusion cell system can be used as a tool for the individual in vitro permeation method designs in the development of a topical or transdermal patch to answer specific questions.

Our speaker for this session is Dr. Julia Lodder-Gadaczek from LTS Lohmann Therapie-Systeme AG, a worldwide transdermal market leader.

Mastering In Vitro Permeation Testing: A Comprehensive Guide to Conducting an IVPT Study

May 16, 2023

In this webinar, we cover skin preparation, diffusion cell preparation, the barrier integrity test, how to apply dosage form, steps to take after the treatment period, and analysis. We’ll discuss the proper technique, equipment and methodologies used in IVPT, and the regulatory guidance available. By the end of this webinar, you will h​ave a deeper understanding of IVPT and the essential steps required to conduct a successful study. You will receive a detailed overview, including videos, on how best to conduct In Vitro Permeation Testing (IVPT) studies.

Our speaker for this session is Hanan Osman-Ponchet, founder and CEO of PKDERM and an expert in IVPT testing.

In Vitro Permeation Testing (IVPT): Application to Cosmetic Products

November 2022

The objective of in vitro permeation testing (IVPT) is to measure the absorption and diffusion of cosmetic products/ingredients into and across the skin. Please join Teledyne Hanson and PKDERM for this informative 45-minute webinar, followed by an interactive Q&A offering you an opportunity to address your specific application.

Our speaker for this session is Hanan Osman-Ponchet, founder and CEO of PKDERM and an expert in IVPT testing.

During the webinar, you’ll learn how, when and why to perform IVPT in your lab, the differences between pharma and cosmetic testing, and the precautions to take when performing IVPT. IVPT is conducted using Franz-type diffusion cells and are performed according to OECD GD 428 and to SCCS/1358/10. Data generated using this predictive in vitro model are important for safety evaluation of cosmetic ingredients and are used to fill up the exposure and toxicological profile sections of the Cosmetic Product Safety Report as required by the EU Cosmetic Regulation 1223/2009.

Comparative Study of Different Membranes Modeling Skin Penetration

October 2022

The human skin is marked as a standard by regulatory agencies in the permeation study of dermal formulations. Artificial membranes can substitute human skin to some extent.

We invite you join us for this informative, 45-minute webinar, followed by an interactive Q&A session, sponsored by Teledyne Hanson and presented by Szilvia Berkó, PharmD, PhD., with the Institute of Pharmaceutical Technology and Regulatory Affairs in Szeged, Hungary.

Academicians and pharmaceutical corporations are focusing their efforts on developing standardized protocols and safe, reliable options to substitute human skin for carrying out permeability studies. This webinar demonstrates the applicability of different membranes using the Franz diffusion cell method and presents a supporting technique for a more relevant evaluation of the results.

Highlights include:

• A description of the requirements for the experimental conditions of the Franz diffusion cell method
• The difference between synthetic and biological membranes and their application possibilities
• Some results and conclusions of the experimental tests carried out using the Franz diffusion cell method with different membranes.

Introduction to In Vitro Permeation Testing (IVPT): Strengths and Weaknesses

April 2022

The FDA's Acyclovir IVPT guidance can be complicated. During this presentation, we will review the FDA's draft guidance, discuss its strengths and weaknesses, and offer suggestions for strengthening the test.

Following the presentation, you'll have a valuable and unique opportunity to gain expert answers to your questions specific to IVPT in your lab. Teledyne Hanson representative Bruna Lousada also will offer information on the company's IVPT-related instruments, products and services.

Speakers

• Clive Roper, director of Roper Toxicology Consulting Ltd.
• Frank Toner, associate director of In Vitro Dermal Services at Charles River Laboratories

The presentation is sponsored by Teledyne Hanson, the leading global technology company specializing in analytical test instruments for the pharmaceutical industry for more than 70 years.

In Vitro Bioequivalence Testing of Topical Generic Products

January 2022

The webinar on diffusion testing of transdermal products entitled, “In Vitro Bioequivalence Testing of Topical Generic Products: Advances and Challenges in Validated Methods and Regulatory Compliance” was recently presented by Diteba Laboratories and sponsored by Teledyne Hanson.

The Teledyne Hanson Phoenix dry heat diffusion systems make diffusion-cell testing faster, easier, and more economical. The Phoenix DB-6 manual sampling system offers six-cell manual sampling in a compact footprint with an advanced touch screen display. The Phoenix RDS Robotic Diffusion Station fully automates sampling, collection, and media replace with the ability to run up to 24 cells at once. Both systems rely on the new Phoenix™ dry heat diffusion cell, made from precision borosilicate glass, with mixer inserts engineered to produce instant homogenization of receptor media.

Advancements in Sample Preparation Techniques for Solid Dosage Forms

January 2022

The webinar entitled, “Advancements in Sample Preparation Techniques for Solid Dosage Forms” was recently presented by Dr. Richard Ladd and Dr. Hugh Malkin, and sponsored by Teledyne Hanson.

The Teledyne Hanson XTRX500 Sample Preparation Extractor provides lightning fast extraction of API from solid dosage forms. The rapid and reproducible extraction process of the XTRX500 is made possible by its powerful crushing mechanism combined with forced-jet mixing, single-use pouches, and a programmable interface.​

Transcending Transdermal Delivery

November 2021

This informative webinar on transdermal drug delivery strategies. Speakers include Dr. Ashvin Patel, Director of Analytical Research & Business Development for Teledyne Hanson, Elise Dauphin-Chanard, Application Lab Manager at Gattefossé, and Bruna Lousada, European Sales & Marketing Manager for Teledyne Hanson.

The Teledyne Hanson Phoenix dry heat diffusion systems make diffusion‐cell testing faster, easier, and more economical. The Phoenix DB‐6 manual sampling system offers six‐cell manual sampling in a compact footprint with an advanced touch screen display. The Phoenix RDS Robotic Diffusion Station fully automates sampling, collection, and media replace with the ability to run up to 24 cells at once. Both systems rely on the new Phoenix™ dry heat diffusion cell, made from precision borosilicate glass, with mixer inserts engineered to produce instant homogenization of receptor media.

Introduction to IVRT: Fundamentals of In Vitro Release Testing of Semisolid Dosage Forms

May 2021

This informative webinar on in vitro release testing (IVRT) of semisolid dosage forms, moderated by Keith Hamman, Vice President and General Manager, Teledyne Hanson, and presented by RaDes GmbH's Sascha Gorissen, Lab Operations Manager, and Michael Herbig, CEO.

The Teledyne Hanson Phoenix dry heat diffusion systemsmake diffusion-cell testing faster, easier, and more economical. The Phoenix DB-6 manual sampling system offers six-cell manual sampling in a compact footprint with an advanced touch screen display. The Phoenix RDS Robotic Diffusion Station fully automates sampling, collection, and media replace with the ability to run up to 24 cells at once. Both systems rely on the new Phoenix™ dry heat diffusion cell, made from precision borosilicate glass, with mixer inserts engineered to produce instant homogenization of receptor media.