Special grooves machined into the tops and sides of the mixer-inserts provide strong circulation and nearly instantaneous homogenization of cell contents. This system prevents the formation of regions of higher concentration of API under the membrane, thereby reducing test variability.
Phoenix cells are quick to set up. Dosage forms are applied to an easily accessible opening in the cell cap. No clamps are required. Bubbles are easily detected and removed simply by lifting the cell and tipping it to one side.
The Phoenix press-on style of cell cap is made from polyether ether ketone (PEEK), sealed with O‑rings made from Viton™ (fluoroelastomer). The Phoenix threaded style of cell cap is made from polytetrafluoroethylene (PTFE), sealed with O-rings made from either Viton or Kalrez™ (perfluoroelastomer) for higher compatibility with aggressive solvents such as THF and DMSO.
As each diffusion cell, mixer, and cell cap has its own serial number, traceability and process control are improved.
Broad Range of Test Parameters
With three sizes of diffusion cells, short and tall mixer-inserts for each, and a variety of cell cap designs and sizes, the Phoenix platform provides analysts with a broad range of diffusion cell testing capabilities. Receptor media volumes range from 10 mL to 30 mL, dosage volumes from 0.25 mL to 6.3 mL and orifice diameters 9 mm to 20 mm.
* Volumes shown are nominal; actual volumes will vary and are determined by measurement of each specific diffusion cell assembly in the lab.